James S McCarthy Selected Research

Parasitemia

6/2022	Transmission blocking activity of low dose tafenoquine in healthy volunteers experimentally infected with Plasmodium falciparum.
1/2022	Parasite Viability as a Measure of In Vivo Drug Activity in Preclinical and Early Clinical Antimalarial Drug Assessment.
1/2022	Antimalarial Activity of Artefenomel Against Asexual Parasites and Transmissible Gametocytes During Experimental Blood-Stage Plasmodium vivax Infection.
11/2021	Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine.
1/2021	Defining the Antimalarial Activity of Cipargamin in Healthy Volunteers Experimentally Infected with Blood-Stage Plasmodium falciparum.
1/2020	Early Endothelial Activation Precedes Glycocalyx Degradation and Microvascular Dysfunction in Experimentally Induced Plasmodium falciparum and Plasmodium vivax Infection.
1/2020	An Experimental Human Blood-Stage Model for Studying Plasmodium malariae Infection.
1/2019	DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum.
1/2019	Antiphosphatidylserine Immunoglobulin M and Immunoglobulin G Antibodies Are Higher in Vivax Than Falciparum Malaria, and Associated With Early Anemia in Both Species.
1/2019	Blood Schizonticidal Activity and Safety of Tafenoquine When Administered as Chemoprophylaxis to Healthy, Nonimmune Participants Followed by Blood Stage Plasmodium falciparum Challenge: A Randomized, Double-blind, Placebo-controlled Phase 1b Study.

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James S McCarthy Research Topics

Disease

79	Infections 06/2022 - 02/2002
77	Malaria 06/2022 - 12/2004
22	Parasitemia 06/2022 - 02/2006
11	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2022 - 12/2014
11	Scabies (Sarcoptic Mange) 01/2021 - 07/2009
5	Hookworm Infections (Hookworm Infection) 12/2021 - 01/2011
5	Vivax Malaria 11/2020 - 06/2012
4	Filarial Elephantiasis (Lymphatic Filariasis) 04/2013 - 04/2008
3	Bites and Stings (Sting) 01/2020 - 06/2016
2	Exanthema (Rash) 12/2021 - 01/2019
2	Glucosephosphate Dehydrogenase Deficiency 01/2021 - 01/2020
2	Pharyngitis (Sore Throat) 01/2021 - 01/2019
2	Celiac Disease (Celiac Sprue) 12/2020 - 03/2011
2	Trichuriasis 01/2020 - 01/2014
2	Acute malaria 01/2020 - 12/2014
2	Convalescence 01/2020 - 01/2017
2	Communicable Diseases (Infectious Diseases) 12/2019 - 10/2014
2	Fever (Fevers) 01/2019 - 02/2016
2	Persistent Infection 03/2012 - 03/2011
2	Acquired Immunodeficiency Syndrome (AIDS) 02/2012 - 01/2012
2	Helminthiasis (Helminthiases) 01/2012 - 01/2010
2	Coinfection 01/2012 - 12/2004
2	Onchocerciasis 01/2010 - 03/2003
1	COVID-19 01/2021
1	Hemolytic Anemia 01/2021
1	Babesiosis (Piroplasmosis) 12/2019
1	Loiasis 12/2019
1	Anemia 01/2019

Drug/Important Bio-Agent (IBA)

26	Pharmaceutical PreparationsIBA 01/2022 - 05/2010
23	Antimalarials (Antimalarial Agents)IBA 01/2022 - 01/2011
23	VaccinesIBA 12/2021 - 02/2002
9	AntigensIBA 01/2019 - 09/2011
8	AntibodiesIBA 01/2021 - 03/2003
8	Proteins (Proteins, Gene)FDA Link 09/2019 - 01/2011
8	1- acetyl- 1,2,3,3a,8,8a- hexahydro- 8a- hydroxy- 5- methoxypyrrolo(2,3- b)indole (CHMI)IBA 01/2018 - 04/2015
7	CytokinesIBA 02/2021 - 07/2007
7	Ivermectin (Mectizan)FDA Link 03/2019 - 11/2006
6	artemisinin (artemisinine)IBA 02/2022 - 01/2020
6	Biomarkers (Surrogate Marker)IBA 12/2021 - 10/2014
6	Malaria VaccinesIBA 01/2018 - 01/2010
5	Albendazole (Albenza)FDA Link 12/2021 - 02/2009
5	Chloroquine (Aralen)FDA LinkGeneric 11/2020 - 05/2012
5	Histidine (L-Histidine)FDA Link 01/2019 - 01/2011
4	piperaquineIBA 06/2022 - 07/2016
4	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 01/2022 - 01/2019
4	Transaminases (Aminotransferases)IBA 01/2022 - 01/2018
4	artefenomelIBA 01/2022 - 01/2016
4	DSM265IBA 12/2021 - 01/2017
4	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 01/2016
4	HLA-DR Antigens (HLA-DR)IBA 01/2020 - 01/2016
4	Interleukin-10 (Interleukin 10)IBA 01/2019 - 01/2011
4	AnthelminticsIBA 12/2016 - 01/2010
4	Lopinavir FDA Link 05/2012 - 02/2006
4	Ritonavir (Norvir)FDA Link 05/2012 - 02/2006
3	tafenoquineIBA 06/2022 - 01/2019
3	Antiparasitic Agents (Antiparasitics)IBA 06/2022 - 12/2016
3	ArtesunateIBA 01/2022 - 02/2016
3	InterferonsIBA 01/2021 - 01/2018
3	Glutens (Glutelin)IBA 12/2020 - 01/2011
3	Complement System Proteins (Complement)IBA 09/2019 - 03/2015
3	Indicators and Reagents (Reagents)IBA 01/2019 - 08/2015
3	Hemoglobins (Hemoglobin)IBA 01/2019 - 03/2011
3	Mefloquine (Lariam)FDA LinkGeneric 01/2017 - 01/2016
3	Protease Inhibitors (Protease Inhibitor)IBA 05/2012 - 02/2006
3	EnzymesIBA 05/2010 - 03/2003
2	ZY-19489IBA 01/2022 - 01/2022
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 06/2006
2	C-Reactive ProteinIBA 01/2021 - 01/2019
2	Primaquine FDA Link 01/2021 - 06/2012
2	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 01/2021 - 01/2019
2	MMV390048IBA 12/2020 - 01/2020
2	RNA (Ribonucleic Acid)IBA 01/2020 - 01/2017
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 01/2016
2	Sulfides (Thioethers)IBA 01/2018 - 10/2015
2	moxidectinIBA 01/2017 - 03/2016
2	Saquinavir (Invirase)FDA Link 05/2012 - 02/2006
2	Nevirapine (Viramune)FDA Link 02/2012 - 01/2012
2	Permethrin (Ambush)FDA LinkGeneric 05/2010 - 02/2010
2	ImmunosorbentsIBA 04/2008 - 03/2003
1	ruxolitinibIBA 01/2022
1	Prednisolone (Predate)FDA LinkGeneric 12/2021
1	Peptide Elongation Factor 2 (EF-2)IBA 12/2021
1	flt3 ligand protein (flt3 ligand)IBA 02/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	artenimol (dihydroartemisinin)IBA 01/2021
1	NITD 609IBA 01/2021
1	streptolysin OIBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	deoxyribonuclease BIBA 01/2021
1	1-Phosphatidylinositol 4-Kinase (1 Phosphatidylinositol 4 Kinase)IBA 12/2020
1	OsteoprotegerinIBA 01/2020
1	SJ733IBA 01/2020
1	InsecticidesIBA 03/2019

Therapy/Procedure

16	Therapeutics 02/2022 - 06/2006
7	Mass Drug Administration 07/2019 - 01/2010
4	Aftercare (After-Treatment) 01/2022 - 01/2016
4	Drug Therapy (Chemotherapy) 12/2019 - 11/2006
3	Chemoprevention 01/2019 - 02/2005
1	Intravenous Administration 10/2021
1	Blood Component Removal (Apheresis) 12/2019